Food allergy and anaphylaxis – 2045. Highly elevated IgE antibodies to vaccine components in influenza vaccine-associated anaphylaxis in Japan

Background Anaphylaxis after vaccination is rare but significant problem since it may be fatal without prompt treatment. Proper diagnosis and identification of the causative agent is critical for management and prophylaxis of the anaphylaxis. Influenza vaccine-associated anaphylaxis (IVA) has been related to egg allergy since influenza vaccines are produced in embryonated eggs. However, patients with IVA do not always have egg allergy. In 2011-12 season, increase in incidence of IVA was reported from one manufacturer in Japan (approximately, 1 in 1.4 million doses in regular years and 1 in 0.4 million doses in 2011).